运动期间心脏功能障碍在患有支气管肺功能障碍的年轻成年人中
Jarno J Steenhorst1,2,3, Willem A Helbing2,3, Wouter J van Genuchten2
1Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
ERJ open research
|June 18, 2024
概括
过早出生的年轻人,特别是患有支气管肺功能障碍 (BPD) 的年轻人,表现出心脏功能受损和运动表现不佳. 这些发现表明,在这个人群中,未来患心脏病的风险更高.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 新生儿科学 新生儿科学
背景情况:
- 1-2%的儿童出生得早产,面临支气管肺功能失调 (BPD) 和早期心血管疾病的风险.
- BPD在长期心血管健康中的具体作用尚不清楚.
- 过早幸存者是一个不断增长的人口,具有潜在的长期健康影响.
研究的目的:
- 在极度早产幸存者的年轻成年人中,在亚最大运动期间调查心肺呼吸功能.
- 为了比较BPD和没有BPD的早产幸存者的运动能力和心脏反应,与按期出生的对照进行比较.
- 在这个队列中识别心血管疾病的潜在早期标志物.
主要方法:
- 40名早产的年轻成年人 (20名患有BPD,20名没有) 与年龄相匹配的早产成年人进行了前性比较.
- 在次最大运动期间利用最大心肺运动测试 (CPET) 和心血管磁共振 (CMR).
- 评估休息心率,氧气吸收峰值,以及运动期间心脏体积变化.
主要成果:
- 与按时出生的对照人群相比,患有BPD的早产儿表现出更高的静止心率和较低的氧气吸收峰值.
- 在BPD组中观察到心脏中风体积对运动的反应受损.
- 在早产幸存者,特别是患有BPD的运动期间,左心室末期扩张体积下降更为显著.
结论:
- 过早出生的年轻人,特别是患有BPD的年轻人,表现出休息时心脏功能受损,运动表现和心脏适应运动.
- 运动期间的心血管磁共振可以识别容易患晚年心脏病的个体.
- 早期识别和监测早产幸存者的心血管健康至关重要.
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