血清calprotectin侧流测试作为急性肺部感染的炎症和预后标记:一个前性观察性研究
Amy Gilmour1,2, Chloe Hughes1,2, Yan Hui Giam1
1Molecular and Clinical Medicine, University of Dundee, Dundee, UK.
ERJ open research
|June 18, 2024
概括
血清S100A8/A9 (calprotectin) 的快速测试与临床数据相结合,预测了住院COVID-19患者的预测结果. 这种方法确定了与中性粒细胞激活标志物相关的患者群.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 住院治疗COVID-19的病例呈现出不同的临床轨迹.
- 中性粒细胞活化与严重的COVID-19病原体产生有关.
- 生物标志物对于住院患者的准确预后是必要的.
研究的目的:
- 为了评估一个快速的,定量血清S100A8/A9 (calprotectin) 侧流试验.
- 评估S100A8/A9与COVID-19结果的临床状态相结合的预测值.
- 为了识别与中性粒细胞激活标志物相关的患者群.
主要方法:
- 开发和验证一种血清S100A8/A9侧流检测方法.
- 住院COVID-19患者的前性队列研究.
- 对S100A8/A9水平,临床数据和患者结果的相关性分析.
- 基于中性粒细胞激活标记物的聚类分析.
主要成果:
- S100A8/A9侧流试验提供了快速的定量结果.
- 结合S100A8 / A9水平和临床状态显著预测了患者的结果.
- 鉴定出了一个独特的患者群体,其特征是中性粒细胞激活标志物升高.
结论:
- 血清S100A8/A9测量是COVID-19预后的一个有价值的工具.
- 这种生物标志物与临床评估的结合提高了结果的预测.
- 中性粒细胞激活在严重的COVID-19病例的一个子集中起着关键作用.
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