在一般人群中,COVID-19相关的大脑微型血液
Malini V Sagar1, Neus R Ferrer2, Mostafa Mehdipour Ghazi2
1Department of Neurology, Copenhagen University Hospital-Herlev and Gentofte, Herlev 2730, Denmark.
Brain communications
|June 18, 2024
概括
大脑微出血,在MRI上检测到的小脑出血,在COVID-19感染的个体中更常见. 这种关联表明病毒和这些发现之间存在潜在的联系,即使在非住院患者中也是如此.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 大脑微型血流是脑MRI上常见的偶然发现.
- 之前的研究指出,在重病的2019年冠状病毒疾病 (COVID-19) 患者中,微型血液.
- 在非住院患者中,COVID-19和微型血液之间的关联不太清楚.
研究的目的:
- 在非住院COVID-19患者的MRI上调查大脑微型出血的风险.
- 为了比较COVID-19感染者与未感染者之间的微型血液的流行率.
- 探索SARS-CoV-2感染与大脑微型血液发育之间的潜在联系.
主要方法:
- 追溯病例控制研究,包括18岁以上的患者,受敏感度加权序列MRI.
- 病例是COVID-19阳性 (RT-PCR证实SARS-CoV-2),与基于年龄,性别,BMI和并发症的三个非暴露对照相匹配.
- 人工智能被用来在MRI扫描上量化大脑微型血流.
主要成果:
- 包括73例COVID-19病例和219个匹配的对照.
- COVID-19 感染与大脑微型出血的可能性更高 (OR 2.66) 有关.
- 当排除痴呆症患者和住院患者时,这种关联更为强烈.
结论:
- 大脑微出血可能与COVID-19感染有关,即使在非住院患者中也是如此.
- 这一发现有助于理解COVID-19的背景下微型血液的病理生理学.
- 这可能有助于解释在有COVID-19病史的患者中观察到的偶然的微型血流.
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