治疗非结核性菌根菌:挑战和前景
Liberty E Conyers1, Bernadette M Saunders1
1School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.
Frontiers in microbiology
|June 18, 2024
概括
非结核菌菌 (NTM) 感染在全球范围内不断增加,目前对Mycobacterium avium复合物的治疗方法不足于最佳. 迫切需要新的治疗策略来对抗这些持久的机会性感染.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 非结核菌 (NTM) 是机会性病原体,其全球发病率正在增加.
- 目前针对NTM感染的治疗方案,特别是Mycobacterium avium复合体,是长时间的,并表现出不理想的疗效.
- 复发和再感染的高率需要紧急开发新的治疗干预措施.
研究的目的:
- 审查正在进行的新型NTM疗法的临床试验.
- 为了确定NTM感染的新兴治疗策略和药物组合.
- 突出NTM治疗开发中的挑战和未得到满足的需求.
主要方法:
- 针对NTM感染的干预抗生素试验的系统调查在ClinicalTrials.Gov.上进行.
- 搜索术语包括特定的NTM物种和一般的NTM命名法.
- 纳入标准侧重于基于抗生素的干预研究.
主要成果:
- 大多数正在进行的试验涉及剂量优化或现有治疗方法的组合治疗.
- 新兴的疗法经常包括阿米卡辛,克洛法齐明,阿兹特罗米辛,贝达基林和林氏.
- 在NTM治疗开发中的挑战包括生物膜形成,独特的细胞壁和获得/内在抵抗.
结论:
- 迫切需要增加投资,开发有针对性的NTM疗法.
- 目前的研究重点是改进现有治疗方法,而不是完全新的方法.
- 解决NTM特异性耐药机制对于未来的治疗成功至关重要.
关键词:
这种细菌是Mycobacterium abscessus.这种细菌是Mycobacterium avium.非结核性菌根杆菌是没有结核的.抗生素 抗生素是一种抗生素.临床试验是指临床试验中的临床试验.治疗方案的治疗制度.更多相关视频
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