工程纳米系统的进展:用于治疗应用的免疫调节相互作用
Rupam Khatua1, Bibrita Bhar1, Souradeep Dey2
1Biomaterials and Tissue Engineering Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati - 781039, Assam, India. biman.mandal@iitg.ac.in.
Nanoscale
|June 18, 2024
概括
纳米粒子 (NP) 通过调节免疫系统以向药物输送和疾病治疗,提供先进的治疗潜力. 本综述探讨了NP的创新应用及其在免疫细胞上的机制,强调了临床进展.
科学领域:
- 免疫学 免疫学 免疫学
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 纳米粒子 (NP) 越来越多地被用于它们的治疗潜力,包括免疫调节,药物输送和疫苗辅助剂.
- 通过NP针对性地提供治疗剂可以提高疗效,并通过将影响集中在疾病部位来最大限度地减少系统性副作用.
- 像大小,形状,电荷和表面修饰等NP属性对它们的生物相互作用产生了重大影响.
研究的目的:
- 审查使用纳米粒子进行免疫系统调节的新兴和创新方法.
- 检查各种纳米粒子类型,材料及其在免疫治疗中的特定应用.
- 提供对治疗性NP对关键免疫成分的机械效应的见解.
主要方法:
- 基于纳米粒子的免疫调节策略的综合文献综述.
- 分析NP特性及其对免疫细胞相互作用的影响.
- 专注于详细介绍NP对T细胞,B细胞,巨细胞,树突细胞和补充系统的影响的机制研究.
主要成果:
- 纳米粒子在调节免疫反应以获得治疗效益方面显示出显著的潜力.
- 目前正在为向免疫疗法开发多种NP材料和设计.
- 了解NP-免疫细胞相互作用对于优化治疗结果至关重要.
结论:
- 纳米粒子技术正在彻底改变向免疫疗法,提高疗效,减少副作用.
- 对NP-免疫系统相互作用的进一步研究将打开新的治疗范式.
- 免疫调节纳米药物的临床翻译显示出有希望的未来前景.
更多相关视频
11:07Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination
Published on: April 29, 2015
13.2K
06:26Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
Published on: January 24, 2025
979
相关概念视频
01:27Tumor Immunotherapy
511
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
511
01:27Cytotoxic T Cells-mediated Immune Response
889
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
889
01:40Cell-mediated Immune Responses
68.1K
Overview
68.1K