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史蒂文斯-约翰逊综合征患者的 Lid 边缘微生物组 患有 Lid 边缘角质化和严重干眼疾病的患者
Swati Singh1, Moumi Maity1,2, Swapna Shanbhag3
1Center for Ocular Regeneration (CORE), L. V. Prasad Eye Institute, Hyderabad, Telangana, India.
Investigative ophthalmology & visual science
|June 18, 2024
概括
患有史蒂文斯-约翰逊综合征 (SJS) 的患者的盖膜边缘微生物组发生了显著的变化,与健康个体相比,其多样性减少,异质性增加. 这项研究突出了SJS患者的关键细菌差异.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 皮肤病学 皮肤病学
背景情况:
- 慢性史蒂文斯-约翰逊综合征 (SJS) 可以导致显著的眼睛表面并发症,包括眼边缘的改变.
- 眼睛表面微生物组在维持眼睛健康方面发挥着至关重要的作用,其失能症与各种眼睛疾病有关.
研究的目的:
- 评估慢性史蒂文斯-约翰逊综合征 (SJS) 和角质化边缘患者的边缘微生物群.
- 为了将SJS边缘微生物组与健康对照组和患有梅博米腺功能障碍 (MGD) 的患者进行比较.
主要方法:
- 16S rDNA V3-V4变量区域的下一代测序在10名SJS患者和20名健康对照者的眼边缘拭子上进行.
- 在SJS患者中,角质化眼边缘的微生物组也与相邻的眼皮肤进行了比较.
主要成果:
- 与健康对照组相比,SJS盖边缘微生物群的多样性较低,异质性更大.
- 包括Corynebacterium和Haemophilus在内的特定属在SJS患者中增加,而Acinetobacter则减少.
- 在SJS患者的角质膜边缘微生物组和MGD患者的历史微生物组之间观察到显著的差异.
结论:
- 在患有SJS和角质化膜边缘的患者中,膜边缘微生物组发生了显著的变化.
- 这些变化不同于SJS患者的眼皮肤微生物群和健康个体或MGD患者的微生物群.
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