一个简单而敏感的测试,用于Candida auris殖民,监视和感染控制,适合在患者附近使用
Sukalyani Banik1, Burcu Ozay2, Marisol Trejo3
1Center for Emerging Pathogens, Department of Medicine, Public Health Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Journal of clinical microbiology
|June 18, 2024
概括
开发了一种用于Candida auris监测的新快速测定方法. 这种敏感和特定的测试可以在不到一个小时的时间内从皮肤拭子中检测出多药耐药性真菌,有助于预防医疗保健爆发.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 诊断试验开发 诊断试验开发
背景情况:
- 黄是一种多药耐药的酵母菌,在医疗机构中引起侵入性感染.
- C. auris殖民于患者,并持续存在表面,使感染控制复杂化.
- 目前的监控方法可能缺乏及时干预所需的速度和整合.
研究的目的:
- 开发和验证一种快速的,对Candida auris.的护理点监测测定.
- 为了在医疗环境中及时检测和控制C. auris.
- 为防止殖民和疫情爆发提供一种工具.
主要方法:
- 为检测C. auris而开发了一种原型基于弹药盒的测定方法 (CaurisSurV).
- 在GeneXpert仪器上进行综合样本处理和核酸放大.
- 使用来自两个机构的临床皮肤抹布样本进行验证,并使用非C. auris菌株进行分析测试.
主要成果:
- 该试验表明,C. auris. 的检测极限低至10.5 CFU/mL.
- 获得了高的联合灵敏度 (97.5%与培养相比,92%与PCR相比) 和100%的特异性.
- 完整的测定在58分钟内提供了结果,检测了所有五种C. auris类.
结论:
- 一种敏感,特异和快速的原型检测方法已成功开发,用于对C. auris进行监测.
- 综合性点诊断测试可以帮助医疗机构的例行监测和疫情预防.
- 这种工具为有效及时控制C. auris感染提供了潜在的解决方案.
关键词:
它们是Candida auris.基因Xpert 是一个专家.测试试验 测试试验 测试试验殖民化 殖民化的殖民化护理点的护理点.一个简单的测试,简单的测试.皮肤片 皮肤片特定的测试 特定的测试 特定的测试监控监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督测试 测试 测试 测试 测试更多相关视频
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