通过基因定型检测发现的一种单源病房感染的Aspergillus flavus疫情
A Gewecke1, R Krøger Hare1, C Salgård2
1Mycology Unit, Department for Bacteria, Parasites, and Fungi, Statens Serum Institut, Copenhagen, Denmark.
Microbiology spectrum
|June 18, 2024
概括
微卫星基因型鉴定确定了一种特定的Aspergillus flavus克隆,导致了医院爆发. 这种分子工具有助于确定内部来源,使得有针对性的环境清洁和保护弱势患者.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 医院流行病学 医院流行病学
背景情况:
- 在医院获得的Aspergillus flavus感染对免疫功能低下的患者构成重大威胁.
- 在建筑工程 (2017-2019) 期间,在儿科患者中观察到A. flavus感染的增加,其中许多人接受了AMPHOTERICIN B预防治疗.
研究的目的:
- 使用分子方法调查和描述Aspergillus flavus感染的潜在爆发.
- 在医院环境中识别A. flavus的来源和传播动态.
主要方法:
- 微卫星基因型鉴定用于分析153个临床和环境A. flavus分离物.
- 集群分析是使用最小跨度树 (MST) 和主要组件差异分析 (DAPC) 进行的.
- 在受影响的病房中进行了环境空气采样.
主要成果:
- DAPC和MST分析揭示了一组独特的A. flavus分离物,包括爆发病例和环境样本.
- 疫情被追溯到医院内部的来源,在技术医院中发现了高A. flavus流行率.
- 封闭确定的环境来源导致了负的后续空气样本.
结论:
- 微卫星基因型鉴定是记录同源性医院疫情和识别内部来源的宝贵工具.
- 快速识别来源和控制措施对于管理A. flavus疫情至关重要.
- 建议保护易受伤害的患者,并提前将基因型鉴定纳入调查.
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