相关实验视频
Updated: Jun 23, 2025

08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
15.7K
皮肤转移:从流行病学到治疗
Martin Gschnell1, Christian Volberg2,3, Christina Hauser1
1Department of Dermatology and Allergology, University Hospital of Marburg, Philipps University Marburg, Marburg, Germany.
概括
皮肤转移,癌症的皮肤扩散,影响高达10%的瘤患者. 本综述涵盖了管理这些具有挑战性的皮肤疾病的诊断和治疗策略.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 癌症研究 癌症研究
背景情况:
- 皮肤转移是瘤学中显著的临床表现,影响高达10%的癌症患者.
- 这些皮肤转移会导致严重的心理痛苦,包括羞耻和社会退缩,特别是当它们被除时.
- 皮肤转移的位置和表现因原发性癌症类型而异.
研究的目的:
- 为皮肤转移的诊断方法提供全面的概述.
- 审查当前的局部和全身治疗选择,以管理皮肤转移.
- 讨论与皮肤转移相关的最常见的原发性瘤实体.
主要方法:
- 对皮肤转移的诊断和治疗策略的文献综述.
- 基于瘤实体的治疗选择当前研究的分析.
- 综合有关心理影响和管理的信息.
主要成果:
- 皮肤转移代表了癌症患者的常见情况,具有不同的临床表现.
- 有有效的诊断工具可用于准确识别皮肤参与.
- 可以使用一系列局部和全身治疗,根据特定的癌症类型和患者量身定制.
结论:
- 准确的诊断和及时管理皮肤转移对于改善患者的治疗结果和生活质量至关重要.
- 多学科的方法往往是必要的,以实现最佳的治疗计划.
- 进一步研究新的治疗策略是有必要的,以应对皮肤转移所带来的挑战.
相关概念视频
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Skin Cancer
4.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K
Tumor Immunotherapy
511
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
511
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K

