设计,优化和评价含有甲基酸盐和蛋白涂层的聚合物纳米粒子
Gaurav Tiwari1, Anasuya Patil2, Pranshul Sethi3
1Department of Pharmacy, PSIT-Pranveer Singh Institute of Technology (Pharmacy), Bhauti, Kanpur, U.P, India.
Journal of biomaterials science. Polymer edition
|June 18, 2024
概括
专纳米颗粒通过阻断排泄输送器,有效地将抗癌药物甲醇向大脑输送. 这种配方显示了药物逐渐释放和最小的细胞毒性,表明潜在的向大脑输送.
科学领域:
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
- 药物运输 药物运输 药物运输
背景情况:
- 甲托雷克萨特是一种有效的抗癌药物,但其疗效受到大脑中的排泄输送器的限制.
- 专可以作为排泄输送阻塞剂,可能会增加大脑中的药物度.
研究的目的:
- 开发和表征含有甲基酸盐的纳米颗粒,以增强大脑输送.
- 评估白素和多巴胺HCl涂层在改善纳米粒子脑向和药物释放方面的潜力.
主要方法:
- 使用乳化溶剂蒸发制备了含有甲的纳米颗粒.
- 纳米粒子的特点是尺寸,多分散度指数 (PDI),泽塔潜力,捕获效率和产量.
- 扫描电子显微镜 (SEM),体外药物释放和细胞活力测试进行.
主要成果:
- 纳米粒子表现出纳米范围的大小 (例如,F5的168nm) 和良好的同质性 (低PDI值,例如,MNP-Alb的0.129).
- 泽塔潜能表明了足够的排斥性相互作用,并且涂层 (白蛋白,多巴胺HCl) 保持了同质性.
- 试验室研究表明,随着纳米颗粒度的增加,甲甲酸盐的逐渐释放和细胞活力下降,这表明有效性与最小的细胞毒性.
结论:
- 白蛋白涂层的甲状腺素纳米颗粒是持续向大脑输送药物的有希望的配方.
- 开发的纳米颗粒显示出向大脑输送甲状腺素的潜力,并降低了全身毒性.
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