安吉奥坦辛二在分配震荡的治疗:一个系统的审查和元分析
Eleni Xourgia, Aristomenis K Exadaktylos1, Athanasios Chalkias
1Department of Emergency Medicine, Inselspital, University Hospital, University of Bern, Bern, Switzerland.
Shock (Augusta, Ga.)
|June 18, 2024
概括
ангиотензин II (ATII) 没有降低分布性休克的死亡率,但显著降低了对其他血管抑制剂的需求,而没有增加不良事件. 这使得ATII成为多式压缩器治疗的可行选择.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 耐上腺素阻燃性休克通常需要使用非上腺素血管压缩剂进行救援治疗.
- 关于诸如血管素II (ATII) 等药物在分配性休克中疗效的数据仍然有限.
研究的目的:
- 系统地审查并对血管素II (ATII) 作为分配性休克治疗的疗效进行元分析.
- 评估ATII对所有原因死亡率和血管压缩剂要求的影响.
主要方法:
- 对10项涉及1555名患有分布性休克的患者的研究进行了系统审查和元分析.
- 在PubMed,Scopus和灰色文献中搜索相关结果.
- 使用随机效应模型计算聚合风险比率和平均差异.
主要成果:
- 在ATII和对照组之间,所有原因的死亡率相似 (RR=1.02;95% CI:0.89至1.16).
- 在3小时后,ATII显著降低了诺拉上腺素或诺拉上腺素等效剂量 (MD = -0.06;95%CI: -0.11至 -0.02).
- 在接受ATII的患者中,没有报告增加不良事件的发生率.
结论:
- ангиотензин II (ATII) 在分布性休克患者中没有显示出死亡益处.
- 在3小时后,ATII有助于显著减少辅助血管压缩剂的使用.
- ATII是多式疗法可行的替代性血管压缩剂,旨在最大限度地减少甲基醇胺暴露和相关不良事件.
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