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基于可可黄的咖啡因快溶剂片的制造和表征

Ashok Kumar Janakiraman¹, Joanne Yap¹, Ramkanth Sundarapandian²

¹Department Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia.

Therapeutic delivery

|June 18, 2024

概括

使用可可黄和咖啡因成功开发了快速化片 (FMT). 简单的冰箱冷方法是有效的创建的FMTs满足药库标准的解体和药物释放.

科学领域:

制药技术制药技术制药技术
药物输送系统药物输送系统

背景情况:

快溶性药片 (FMT) 改善了患者的服药,特别是在儿科和老年患者群体中.
传统的药片配方在吞时可能会带来挑战,需要替代剂型.

研究的目的:

开发和描述快片 (FMT) 的物理特性.
用可可黄作为基础和咖啡因作为FMT配方的模型药物.

主要方法:

使用简单的冰箱冷方法来制备含咖啡因的FMT.
使用可可黄作为药片配方的基础材料.

主要成果:

F3配方的分解时间为1.20分钟±0.035,符合欧洲药典的限制.
在60分钟后,F3的累积药物释放量达到88.52%,在75分钟后达到94.08%,符合美国FDA的要求.
所有经过测试的FMT的物理性能都符合药典规格.

结论:

简单的冰箱冷方法是制备快速化的片剂的可行技术.
可可黄是开发具有理想药物释放特征的有效FMT的合适基础.

关键词:

咖啡因咖啡因是一种咖啡因.可可黄是可可黄油中的一种.快速化的药片在体外分解在体外溶解溶解.

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