鼻子抵抗和炎症:慢性鼻炎阻塞性睡眠呼吸暂停的机制
Indu Ayappa1, Robert Laumbach2, Kathleen Black3
1Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
醒着的鼻腔抵抗无法解释世界贸易中心响应者慢性鼻炎 (CRS) 和阻塞性睡眠呼吸暂停 (OSA) 之间的联系. 还可能涉及其他因素,如睡眠鼻腔抵抗或炎症.
科学领域:
- 睡眠医学 睡眠医学
- 环境健康 环境健康
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 在世界贸易中心 (WTC) 响应者中非常普遍.
- 慢性鼻炎 (CRS) 是该人群中OSA的已确定危险因素.
- 在清醒期间鼻子炎症或鼻子阻力升高可能解释CRS-OSA关联.
研究的目的:
- 在WTC响应者中调查将CRS症状与OSA联系在一起的机制.
- 为了确定升高的清醒卧底鼻腔抵抗是否与OSA,CRS或鼻腔炎症生物标志物有关.
主要方法:
- 601名WTC健康计划参与者接受了家庭睡眠呼吸暂停测试.
- 进行了仰卧式前鼻测量和鼻腔洗.
- 在2001年9月11日之前,参与者进行了严重打的查.
主要成果:
- 醒着的卧底鼻腔抵抗与OSA没有关联.
- 患有CRS的参与者表现出鼻子炎症标志物升高,但鼻子耐药性不高.
- 鼻腔炎症标志物与鼻腔抵抗没有相关性.
结论:
- 醒着的鼻腔抵抗不能解释WTC响应者的CRS-OSA关系.
- 这种人群中OSA的病理生理学可能涉及睡眠特异性鼻腔抵抗.
- 其他因素,如supraglottic或全身炎症可能有助于OSA的发展.
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