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Tooth Anatomy01:21

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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Isolation, Processing and Analysis of Murine Gingival Cells
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使用初级牙细胞开发体外3D牙模型.

Christelle Plaza1, Christophe Capallere2, Celine Meyrignac2

  • 1Ashland Specialties France, 655 Route du Pin Montard, 06904, Sophia Antipolis, France. cplaza@ashland.com.

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概括

欧洲化品法规禁止对动物进行试验. 研究人员使用人类细胞开发了一种内部3D牙模型,以评估成分安全性和测试口腔护理配方.

关键词:
在体外3D模型中的3D模型.结合性等价值是什么意思牙上皮质的牙上皮质.

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科学领域:

  • 生物医学工程 生物医学工程
  • 组织工程是组织工程.
  • 化品科学 化品科学

背景情况:

  • 欧盟于2013年3月禁止对化品进行动物试验.
  • 该禁令包括口腔护理成分,需要使用替代的安全性评估方法.
  • 现有的体外牙模型缺乏针对特定研究需求的定制.

研究的目的:

  • 开发一个内部,可定制的3D人类牙模型.
  • 为了使参数调节用于研究口腔疾病和成分毒性.
  • 评估化品成分的生物相容性和配方.

主要方法:

  • 利用组织工程专业知识重建人类口腔组织.
  • 隔离和培养初级人类牙纤维细胞和角质细胞.
  • 构建的牙上皮,胆管等价物和全厚模型.

主要成果:

  • 培养的牙细胞保留了繁殖能力,使组织重建成为可能.
  • 重建的牙组织表现出与体内人类牙模型相似的特征.
  • 开发的模型允许调制各种参数用于研究.

结论:

  • 公司内部的3D牙模型为化品成分的动物试验提供了一个可行的替代方案.
  • 该模型支持对口腔护理产品的全面安全性和有效性评估.
  • 该技术促进了对口腔疾病和成分相互作用的个性化研究.