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相关概念视频

Conserved Binding Sites01:49

Conserved Binding Sites

4.2K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
4.2K

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相关实验视频

Updated: Jun 23, 2025

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

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在石工具预测小说内幕.

Carolina Barra1, Jonas Birkelund Nilsson2, Astrid Saksager2

  • 1Section for Bioinformatics, Health Tech, Technical University of Denmark, Lyngby, Denmark. carolet@dtu.dk.

Methods in molecular biology (Clifton, N.J.)
|June 18, 2024
PubMed
概括

识别病原体抗原对于疫苗开发和了解宿主免疫反应至关重要. 本文回顾了用于预测T细胞和B细胞表位的实验和in silico方法,有助于加速发现.

关键词:
B细胞的表观特征预测Epitope的预测免疫性预测免疫性预测的预测.大型HC的介绍在T细胞表观上.

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Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
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Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope

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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Published on: October 15, 2021

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相关实验视频

Last Updated: Jun 23, 2025

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

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Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
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科学领域:

  • 免疫学 免疫学 免疫学
  • 计算生物学 计算生物学
  • 疫苗学 疫苗学 疫苗学

背景情况:

  • 抗原鉴定对于开发疫苗和诊断至关重要.
  • 从历史上看,实验方法识别了免疫原致病原体碎片.
  • 这些数据为表位和免疫性规则提供了信息,从而导致了预测工具.

研究的目的:

  • 介绍MHC呈现和表位标识的基本概念.
  • 审查用于确定表征的实验方法.
  • 专注于最先进的in silico表位预测方法,包括它们的优点和局限性.

主要方法:

  • 对抗原和表位发现的实验技术的审查.
  • 讨论用于预测T细胞和B细胞表位的in silico工具.
  • 分析当前预测方法的优点和局限性.

主要成果:

  • 关于免疫原致病原体碎片的大量数据存在.
  • 开发了许多用于表位预测的in silico工具.
  • 这些工具加速了新型表征的识别,降低了实验成本.

结论:

  • 对现代免疫学和疫苗设计而言,皮层预测工具是必不可少的.
  • 了解MHC呈现和表位特征是关键.
  • 合理使用预测工具可以提高生物医学研究的效率.