阻塞性睡眠呼吸暂停严重程度与抑郁风险之间的关联:系统性审查和剂量反应元分析
Dong-Fang Zhao1, Yi-Zhu Zhang2, Xue Sun1
1Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
Sleep & breathing = Schlaf & Atmung
|June 18, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 增加了抑郁症的风险,特别是在严重的情况下. 呼吸暂停-呼吸暂停指数 (AHI) 每增加1个单位,抑郁症风险就会上升0.4%.
科学领域:
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 越来越多地被认为是抑郁症状的潜在贡献者.
- 了解OSA严重程度和抑郁症之间的关系对于公共卫生至关重要.
- 以前的研究表明存在联系,但明确的剂量反应关系需要进一步研究.
研究的目的:
- 系统地审查和元分析阻塞性睡眠呼吸暂停严重程度和抑郁症风险之间的剂量反应关系.
- 量化增加呼吸暂停-呼吸暂停指数 (AHI) 对抑郁风险的影响.
主要方法:
- 在多个数据库 (PubMed,EMBASE,Scopus,Web of Science,Cochrane Library,CNKI,SinoMed) 进行了全面的系统文献搜索,截至2023年8月28日.
- 包括18个截面研究,包括3143名参与者进行剂量反应元分析.
- 采用随机效应模型来评估线性和非线性剂量反应关系,并评估出版偏差.
主要成果:
- 与轻度的OSA相比,严重的OSA与明显更高的抑郁症调整风险相关 (RR: 1.34,95% CI: 1.05-1.70).
- 在OSA严重程度和抑郁风险之间发现了显著的线性剂量反应关系.
- 抑郁症的风险增加了0.4%,每小时增加1次呼吸暂停-呼吸暂停指数 (AHI) 的事件.
结论:
- 这一元分析证实了阻塞性睡眠呼吸暂停严重程度和患抑郁症的风险之间存在显著的线性剂量反应关联.
- 患有更严重的OSA的人面临着明显更高的抑郁症风险.
- 这些发现强调了解决OSA严重程度在抑郁症状的管理和预防中的重要性.
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