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Updated: Jun 23, 2025

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
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在瘤学中进行无的I-II期试验的药理测量启用DOse优化 (PEDOOP)

Shijie Yuan1, Zhanbo Huang2, Jiaxin Liu3

  • 1Department of Statistics and Data Science, The University of Texas at Austin, Austin, USA.

Journal of biopharmaceutical statistics
|June 18, 2024
PubMed
概括

药量计启用DOse优化 (PEDOOP) 设计优化了使用患者PK/PD数据的早期瘤学试验. 这种无的两相方法可以确定晚期发育阶段的安全有效剂量.

关键词:
适应性随机化适应性随机化发现剂量发现剂量最好的生物剂量是最佳的.药理动力学是药理动力学的一个方面.药物动力学 药物动力学

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