麻症对膀癌患者的预后影响:系统性审查和元分析
Yinghan Zeng1, Chengna Cai1, Nafen Pan1
1College of Integrative Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
Cancer investigation
|June 18, 2024
概括
在膀癌患者手术后,sarcopenia显著恶化了生存结果,包括整体生存,癌症特异性生存和无复发生存. 这种情况还与术后并发症的增加相关,突出了它对患者预后的关键影响.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 外科手术的结果
背景情况:
- 随着年龄的增长,骨肌肉质量和功能的丧失,即萨尔科佩尼亚,越来越被认为是影响癌症患者结果的重要因素.
- 它在经过手术后的膀癌 (BC) 患者的预后中的特殊作用需要全面评估.
研究的目的:
- 在接受膀癌手术的患者中,系统地评估肉类和生存率 (整体,癌症特异性,无复发) 之间的关联.
- 在这个患者队列中,调查肉类和手术后并发症发生率之间的相关性.
主要方法:
- 在PubMed,Web of Science,Cochrane图书馆和Embase数据库中进行了全面的文献搜索,截至2023年4月7日.
- 对26项选定的研究进行了元分析,涉及1713项最初识别的研究,使用Stata进行了对生存和并发症的数据的综合.
- 研究质量使用纽卡斯尔-太华尺度 (NOS) 进行评估.
主要成果:
- 发现,在膀癌患者中,萨科佩尼亚与较低的整体存活率 (HR: 1.62; 95% CI: 1.43-1.83),癌症特异性存活率 (HR: 1.81; 95% CI: 1.52-2.15) 和无复发存活率 (HR: 1.76; 95% CI: 1.21-2.56) 显著相关.
- 亚组分析证实了 Sarcopenia 和不良预后之间的强烈联系,以及术后并发症的风险增加.
结论:
- 麻症是膀癌患者接受手术的关键负面预后因素,影响多个生存终点.
- 肉类的存在也与术后并发症的可能性更高有关,这表明它在术后风险评估和管理中的重要性.
相关概念视频
01:21Cancer Survival Analysis
342
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
342
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K