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Updated: Jun 23, 2025

Flotation-Based T Cell Isolation, Activation, and Expansion from Human Peripheral Blood Mononuclear Cell Samples Using Microbubbles
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Flotation-Based T Cell Isolation, Activation, and Expansion from Human Peripheral Blood Mononuclear Cell Samples Using Microbubbles

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使用多维双螺旋 (MDDS) 惯性微流体来分离激活的T细胞,用于高效的CAR T细胞制造

Hyungkook Jeon1, Caleb R Perez, Taeyoon Kyung

  • 1Department of Manufacturing Systems and Design Engineering (MSDE), Seoul National University of Science and Technology (SEOULTECH), 232 Gongneung-ro, Nowon-gu, Seoul 01811, Republic of Korea.

Analytical chemistry
|June 18, 2024
PubMed
概括

这项研究使用多维双螺旋 (MDDS) 惯性分类来丰富激活的T细胞用于模拟抗原受体 (CAR) T细胞制造. 这种无标签的过程提高了T细胞的纯度,活力和CAR转导能力,提高了治疗效率.

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相关概念视频

Overview Of Cell Separation And Isolation01:20

Overview Of Cell Separation And Isolation

Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.
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