坦桑尼亚农村儿童腹和没有腹的流行病学和胃肠道病原体的多重定居:一个病例控制研究
Daniel Haile Chercos1, Solomon T Wafula2, John P A Lusingu3
1One Health Bacteriology Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
PloS one
|June 18, 2024
概括
坦桑尼亚幼儿的腹疾病通常与多种肠道病原体有关. 西格拉菌种/肠外侵袭性大肠杆菌 (EIEC) 和诺罗病毒感染在某些情况下与腹有很强的关联.
科学领域:
- 全球健康 全球健康
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 腹性疾病对全球健康构成重大负担,特别是在资源有限的环境中.
- 多个胃肠道 (GIT) 病原体的共同感染经常在症状和无症状的个体中观察到.
- 了解这些共同感染对疾病表现的独特影响对于有效的公共卫生干预至关重要.
研究的目的:
- 研究多个胃肠道 (GIT) 病原体检测对五岁以下儿童腹疾病症状的差异化影响.
- 在坦桑尼亚农村人口中识别与腹相关的特定病原体.
- 分析年龄,病原体共同检测和腹疾病结果之间的关系.
主要方法:
- 一项涉及620名5岁以下儿童的病例控制研究,在坦桑尼亚东北部的农村地区.
- 分析重点是便样本中多种病原体检测.
- 统计方法包括计算几率比率 (OR) 和95%置信区间 (CI) 来评估关联.
主要成果:
- 与对照组相比,患有腹 (病例) 的儿童不太可能患有多个GIT病原体的殖民化 [OR=0.50,95%CI=0.39-0.65].
- 年龄较大与携带多种GIT病原体的可能性更高 [OR=1.02,95% CI=1.01-1.04].
- 石格拉菌种/肠道侵入性大肠杆菌 (EIEC) [OR=2.80,95%CI=1.62-4.83]和诺罗病毒 [OR=2.04,95%CI=1.23-3.39]显著与腹相关,而肠道聚合性大肠杆菌 (EAEC) [OR=0.23,95%CI=0.17-0.33]在对照组中更为普遍.
结论:
- 坦桑尼亚农村五岁以下儿童的腹疾病主要与Shigella spp./EIEC和诺病毒感染有关.
- 这些病原体与腹的相关性取决于年龄.
- 虽然多种病原体的殖民在某些病例中不太常见,但特定的病原体,如Shigella spp./EIEC和诺罗病毒是这种人群中腹的关键驱动因素.
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