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Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes
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半合成葡萄糖合物作为潜在的疫苗候选者,用于对抗甲型流感血球菌的疫苗

Claudia V Kohout1, Linda Del Bino2, Laura Petrosilli1

  • 1Department of Chemistry, Università degli Studi di Milano, Milano, Italy.

Chemistry (Weinheim an der Bergstrasse, Germany)
|June 18, 2024
PubMed
概括

开发了针对Haemophilus influenzae血清型a (Hia) 的合成寡糖类抗原. 这些新型的葡萄糖合物疫苗成功提高了抗体,为抗击Hia感染提供了有希望的策略.

关键词:
碳水化合物 碳水化合物葡萄糖合物 葡萄糖合物甲型流感血球菌 (Haemophilus influenzae) 是一种流感病毒.酸胺酸是一种酸.疫苗 疫苗是一种疫苗.

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Conjugated Proteins02:50

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Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
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