免疫检查点抑制剂在头部和部状细胞癌中的使用:当前的情况和未来的前景
Elinor R Gatfield1, John Tadross2,3,4, William Ince1
1Oncology Centre, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.
Future oncology (London, England)
|June 18, 2024
概括
免疫检查点抑制剂对头部和部状细胞癌有前途. 本综述审查了它们在所有疾病阶段的使用,包括治愈和转移的设置.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 已被批准用于高级头部和部状细胞癌 (HNSCC).
- 目前正在进行的研究正在探索早期阶段的ICI和HNSCC的综合疗法.
研究的目的:
- 审查目前在HNSCC的所有阶段使用ICI的证据.
- 讨论在HNSCC管理中ICI应用的未来方向.
主要方法:
- 对已发表的试验进行系统的文献审查.
- 对正在进行的评估ICI疗效的临床试验进行分析.
- 评估ICI在治疗和转移环境中的使用.
主要成果:
- 在不可切除,复发或转移的HNSCC中建立了ICI.
- 证据正在积累,用于ICI在同时使用,新辅助和辅助HNSCC治疗.
- 纳入ICI的多模式方法正在研究转移性HNSCC.
结论:
- 免疫检查点抑制剂代表了HNSCC治疗的重大进展.
- 需要进行进一步的研究,以优化ICI整合到治疗和高级HNSCC护理中.
- 未来的战略可能会涉及新的组合和ICI的早期管理.
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