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磁性表面打印的聚合物微球与HPLC-MS/MS相结合,用于在水中敏感检测胺类药物

Dongqin Tan¹, Yue Wang¹, Haocheng Fan¹

¹College of Environmental Science and Engineering, Dalian Maritime University, No.1 Linghai Road, Dalian, 116026, China.

Journal of chromatography. A

|June 18, 2024

概括

磁印聚合物微球被开发用于选择性安非他胺检测. 这种方法有效地从水样中提取胺类药物,使用磁性固相提取与HPLC-MS/MS相结合.

科学领域:

分析化学分析化学
材料科学材料科学材料科学
环境科学环境科学

背景情况:

胺类药物是环境水中的一个重大问题.
需要有选择性和高效的方法来检测和清除它们.

研究的目的:

为了合成磁表面印制的聚合物微球 (Fe3O4@MIPs).
开发一种磁性固相提取 (MISPE) 方法,用于检测水样中的安非他命.

主要方法:

皮克林乳液聚合被用来创建Fe3O4@MIPs与N-Methylphenethylamine作为模板.
优化提取参数,包括pH值,吸附剂质量和剂.
使用高性能液态染色学并列三重四极质谱法 (HPLC-MS/MS) 进行检测.

主要成果:

Fe3O4@MIPs对六种安非他命药具有很好的选择性 (印记因子1.82.6).
吸附动力学遵循伪二阶模型,达到>80%的效率.
开发的MISPE-HPLC-MS/MS方法在环境水样中实现了低检测极限 (5.223 ng L-1) 和高回收率 (87.2110%).

结论:

由于具有高选择性,易于分离和可重复使用性,Fe3O4@MIPs是胺提取的有效吸附剂.
MISPE-HPLC-MS/MS方法提供了一种敏感且可靠的方法,用于在复杂的环境矩阵中监测安非他命.

关键词:

氨基胺是一种安非他命.磁性固体相提取磁性固体相提取皮克林乳液聚合物的聚合.污水污水处理污水污水处理表面印记是指表面的印记.

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