内脏脂肪组织区域与不孕症之间的关联:一个横截面分析
Zhiyang Zhou1, Yue Xu1, Gaochen Zhang1
1Obstetrics and Gynaecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China; Shanghai Key Laboratory of Reproduction and Development, Shanghai, China.
Reproductive biomedicine online
|June 18, 2024
概括
内脏脂肪组织面积 (VATA) 的增加,这是腹内脂肪的衡量标准,与女性不孕症的更高患病率有关. 这一发现强调了管理腹部肥胖对生殖健康的重要性.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 肥胖医学 肥胖医学
- 公共卫生 营养 公共卫生 营养
背景情况:
- 腹部内脂肪积累,特别是内脏脂肪组织,越来越多地被认为是代谢风险因素.
- 内脏脂肪组织区域 (VATA) 与女性不孕症之间的关系需要进一步阐明.
研究的目的:
- 调查内脏脂肪组织区域 (VATA) 与成年女性不孕不育的患病率之间的联系.
- 识别可能改变这种关联的潜在人口或临床因素.
主要方法:
- 分析了2013-2018年国家健康和营养检查调查中3013名妇女的数据.
- 使用双能X射线吸收计对内脏脂肪组织区域 (VATA) 的评估.
- 权重多变量逻辑回归模型以确定日志VATA和不孕不育之间的独立关联,并进行子组分析.
主要成果:
- 与非不孕症组相比,不孕症组的女性表现出明显更高的日志VATA (P < 0.001).
- 升高的日志VATA独立地与女性不孕症的患病率增加有关 (OR = 2.453,95% CI 1.278-4.792).
- 这一关联在包括女性<35岁,墨西哥裔美国人,非高血压和非糖尿病患者在内的子组中显著.
结论:
- 腹部脂肪组织面积 (VATA) 的扩大与女性不孕症风险的增加显著相关.
- 需要进一步的研究来澄清VATA对女性不孕症的直接影响,以改善预防和治疗策略.
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