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试管婴儿暴露引起了小鼠代谢表型的代际影响

Miaomiao Ban¹, Wanbing Feng¹, Min Hou¹

¹State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Shandong, China.; Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Shandong, China.

Reproductive biomedicine online

|June 18, 2024

概括

像体外受精 (IVF) 一样,辅助生殖技术 (ART) 可以影响后代的新陈代谢. 试管婴儿后代可能会将代谢变化,如改变的葡萄糖和脂质代谢,传递给自己的后代,需要进一步的研究.

科学领域:

生殖生物学生殖生物学
代谢研究的研究.
遗传学遗传学是一个

背景情况:

辅助生殖技术 (ART),包括体外受精 (IVF),在全球范围内越来越多地使用.
对ART对后代的潜在长期健康影响尚未完全理解.
研究试管婴儿对代谢健康的多代影响至关重要.

研究的目的:

检查从试管婴儿后代转移到下一代的代谢表型的传播.
评估试管婴儿对几代人全身和肝脏葡萄脂代谢的影响.
探索饮食作为IVF诱导的代谢变化中的次要因素的作用.

主要方法:

建立一个试管婴儿小鼠模型.
通过试管婴儿和自然交配产生F1和F2后代.
代谢表型的分析,包括体重,葡萄糖,胰岛素,血清甘油三和肝脏基因表达 (脂质生成,自).

主要成果:

试管婴儿F1雄性表现出体重增加,禁食葡萄糖和胰岛素以及血清甘油三.
在试管婴儿F1小鼠中观察到肝脏脂肪生成和自基因表达的增加.
试管婴儿F1雄性将代谢变化传递给试管婴儿F2雄性,包括增加脂肪沉积和降低胰岛素敏感性,即使没有饮食挑战.

结论:

试管婴儿会影响子孙后代的肝脏葡萄糖脂代谢.
试管婴儿对代谢健康的多代影响需要进一步研究.
了解这些机制可以为治疗不孕症和相关代谢障碍的治疗策略提供信息.

关键词:

在这个过程中,IVF IVF.这是代际的,是代际的.肝脏新陈代谢肝脏的新陈代谢男人血统传输的传输方式

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