抗生素耐药性基因的成本取决于宿主菌株和环境,并可能影响社区组成
Huei-Yi Lai1,2, Tim F Cooper1,3
1School of Natural and Computational Sciences, Massey University, Auckland, New Zealand.
Proceedings. Biological sciences
|June 18, 2024
概括
抗生素耐药性基因 (ARG) 可以给细菌带来健康成本,但它们的持久性受宿主菌株相互作用的影响. 这些互动创建这些互动.
科学领域:
- 微生物学 微生物学
- 遗传学 遗传学是一种遗传学.
- 进化生物学 进化生物学
背景情况:
- 已知抗生素耐药性基因 (ARG) 在抗生素选择下有利于细菌.
- 在抗生素选择较弱或不存在的环境中,ARG的维持程度尚不清楚.
- 根据细菌宿主菌株,ARG的健康效应可能会有很大差异.
研究的目的:
- 为了研究不同细菌宿主菌株的特定ARG的健康后果.
- 为了确定ARG是否会给人带来一致的健身成本,或者影响是否依赖于应变.
- 探索宿主菌株相互作用在没有抗生素压力的情况下维持ARG中的作用.
主要方法:
- 量化了六种ARG在11种不同的Escherichia菌种中的适应性影响. 菌株. 菌株. 这些菌株.
- 分析了编码抗 β-乳酸盐,氨基醇和三甲对抗性的ARG的菌株特异性适应性影响.
- 利用模拟来预测ARG-主机相互作用对电阻动态的影响.
主要成果:
- 三个ARG (*bla*TEM-116, *cat*, *dfrA5*) 一般会对宿主细菌施加一种健康成本.
- 所有测试的ARG在至少一个宿主菌株中都表现出可测量的健康效应.
- 观察到ARG和宿主菌株之间的显著相互作用,影响了健康结果.
结论:
- ARG健身效应不是固定的,并且受到细菌宿主菌株的强烈影响.
- 菌株特异性相互作用可以产生"避难菌株",在没有选择的情况下维持ARG.
- 了解这些相互作用对于预测抗生素耐药性的持续和传播至关重要.
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