围产期抑郁症和母亲心血管疾病的风险:瑞典全国性的研究
Donghao Lu1, Unnur A Valdimarsdóttir1,2, Dang Wei1
1Institute of Environmental Medicine, Unit of Integrative Epidemiology, Karolinska Institutet, Nobels väg 13, 17177 Stockholm, Sweden.
European heart journal
|June 18, 2024
概括
被诊断出患有围产期抑郁症 (PND) 的女性在晚年面临患心血管疾病 (CVD) 的风险明显更高. 这一发现强调了在妇女的长期心血管健康评估中考虑PND的重要性.
科学领域:
- 生殖健康 生殖健康
- 心血管疾病流行病学
- 心理健康和慢性疾病
背景情况:
- 生殖因素越来越多地与女性未来心血管疾病 (CVD) 风险有关.
- 虽然严重抑郁症与心血管疾病有关,但围产期抑郁症 (PND) 后的长期心血管疾病风险在很大程度上仍未被描述.
研究的目的:
- 调查患有围产期抑郁症 (PND) 的女性心血管疾病 (CVD) 的长期风险.
- 评估PND与各种心血管疾病亚型的发病率之间的关联.
主要方法:
- 在瑞典 (2001-2014) 进行的一项全国性基于人口的匹配队列研究,包括55539名患有PND的妇女和545567名匹配的对照.
- 关于PND和CVD的数据是从国家卫生登记处获取的,后续调查持续到2020年.
- 多变量Cox模型被用来估计与PND相关的CVD的危险比率 (HR).
主要成果:
- 患有PND的女性患心血管疾病的风险比未受影响的女性高36% (调整后HR=1.36).
- 与姐妹相比,这种关联也很显著 (调整后HR=1.20),并且在没有先前精神病史的女性中最明显.
- 在高血压疾病 (HR=1.50),缺血性心脏病 (HR=1.37) 和心力衰竭 (HR=1.36) 中观察到风险增加.
结论:
- 围产期抑郁症与中年成人心血管疾病风险增加有关.
- 生殖史,特别是PND,应纳入妇女的心血管风险评估.
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