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长期自愿跑步通过调节胆固醇系统,抗氧化能力和BDNF/PI3K/Akt/CREB通路来改善发育中的小鼠的认知能力

Changjian Wan¹, Lulu Shi², Yuying Lai²

¹School of Physical Education and Health, Jiangxi Science and Technology Normal University, Nanchang, China; Jiangxi Province Key Laboratory of Organic Functional Molecules, Institute of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang, China.

Neuroscience letters

|June 18, 2024

概括

在发育中的小鼠中长期炼显著改善了空间记忆. 这种增强与更好的抗氧化活性,平衡的胆固醇系统,减少亡以及BDNF/PI3K/Akt/CREB通路的激活有关.

科学领域:

神经科学是一个神经科学.
运动生理学运动生理学
分子生物学分子生物学

背景情况:

已知适度的体育炼有利于记忆功能.
了解运动引起的认知改善的分子机制至关重要,尤其是在发育阶段.

研究的目的:

研究长期自愿运动对发育中的小鼠空间记忆的影响.
探索运动与大脑的胆固醇系统,抗氧化剂状态,亡以及BDNF/PI3K/Akt/CREB信号通路的关联.

主要方法:

用Y迷宫和新物体识别 (NOR) 测试来评估空间记忆.
胆固醇系统标记物,抗氧化活性 (catalase,malondialdehyde) 和亡因子通过ELISA量化.
在BDNF/PI3K/Akt/CREB通路中的蛋白质表达被分析使用西方 blot.

主要成果:

长期的自愿轮子运行在发育中的小鼠中增强了空间记忆.
运动增加了海马的乙胆含量和酶活性,同时降低了甲水平并抑制了亡.
在海马体中观察到BDNF,TrkB,PI3K,Akt,CREB和p-CREB的升级.

结论:

长期的自愿运动可以改善发育中的小鼠的空间记忆.
这些益处通过调节胆固醇系统,抗氧化活性和亡来调节.
海马BDNF/PI3K/Akt/CREB通路的激活在运动诱导的记忆增强中起着关键作用.

关键词:

标签: 活动活动活动这就是为什么BDNF是BDNF.在CREB路径上.发展时期发展时期长期的自愿轮子运行.在PI3K中,PI3K是指PI3K.空间记忆是一种空间记忆.

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