与代谢功能障碍相关的脂肪性肝病的性变异性
Alessandro Cherubini1, Sara Della Torre2, Serena Pelusi1
1Department of Transfusion Medicine, Precision Medicine Lab, Biological Resource Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Trends in molecular medicine
|June 18, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 由于荷尔蒙的影响,影响男性和女性的程度不同. 了解这些性别差异是开发个性化MASLD治疗的关键.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一种普遍存在的慢性肝病.
- MASLD表现出显著的两性变异,受性染色体和激素的影响.
- 雌激素通常提供保护,而雄激素与增加MASLD风险有关.
研究的目的:
- 审查性二形态对MASLD发展和进展的影响.
- 探索性激素在MASLD管理中的治疗潜力.
- 在MASLD中强调需要针对性别的个性化医疗方法.
主要方法:
- 文献综述侧重于MASLD的荷尔蒙影响和遗传变异.
- 对MASLD病变发生过程中的性别差异现有研究的分析.
- 讨论针对激素通路的当前和潜在的治疗策略.
主要成果:
- 荷尔蒙因素,特别是雌激素和雄激素,在MASLD中发挥着关键作用.
- 激素影响和遗传变异之间的相互作用会影响MASLD的风险.
- 目前的治疗策略可以改进为性别特定的个性化医学.
结论:
- 性二态是MASLD的一个被低估的因素.
- 针对性与性相关的激素为MASLD治疗提供了有前途的途径.
- 解决性别差异的临床试验对于推进个性化MASLD护理至关重要.
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