识别肠道微生物群具有高特异性的缺血性中风与大血管封闭
Ping He1,2, Chen Jiang1, Jianqiang Ni3
1Department of Neurosurgery Intensive Care Unit, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China.
Scientific reports
|June 18, 2024
概括
像Bifidobacterium这样的特定肠道细菌在大血管封闭 (LVO) 缺血性中风患者中显示出显著的变化. 这些微生物变化与中风严重程度相关,可能有助于早期临床治疗.
科学领域:
- 微生物学 微生物学
- 神经学 神经学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群影响与缺血性中风相关的代谢和免疫过程.
- 了解缺血性中风中的肠道微生物组变化对于治疗进步至关重要.
研究的目的:
- 在大血管封闭 (LVO) 缺血性中风患者中识别肠道微生物群的特定变化.
- 评估肠道微生物群与缺血性中风的临床特征之间的关联.
主要方法:
- 16S rRNA基因测序用于分析LVO患者,脑小血管疾病 (CSVD) 患者和正常对照 (NC) 的便样本.
- 进行了相关性分析,以将微生物丰度与临床数据联系起来,包括NIHSS和mRS得分.
主要成果:
- 在LVO患者中,五种特定的肠道微生物群 (Bifidobacterium属,Butyricimonas,Blautia,Dorea;物种Bifidobacterium_longum) 被显著改变.
- 双菌,蓝菌和Bifidobacterium_longum的丰度与NIHSS分数相关.
- 血清甘油三水平调节了Bifidobacterium/Bifidobacterium_longum和中风严重程度得分之间的关联.
结论:
- 在LVO缺血性中风的早期阶段发现了特定的肠道微生物群变化.
- 这些发现可能有助于有效的临床管理策略LVO缺血性中风.
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