相关实验视频

Updated: Jun 23, 2025

Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells

Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells

Published on: May 2, 2017

基于磁性的新型血液过方法的临床前和首次人体安全研究

Nicole Waalders^1,2, Dirk van Lier^1,2, Jelle Gerretsen^1,2

¹Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Scientific reports

|June 18, 2024

概括

在动物和人类研究中,IL-6-Sieve是一种新型的体外装置,可以安全地去除interleukin-6 (IL-6). 这种血液净化技术在治疗炎症性疾病方面表现有前途.

科学领域:

生物医学工程生物医学工程
免疫学免疫学免疫学
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

通过体外装置去除细胞因子是一种潜在的辅助治疗炎症性疾病.
IL-6-Sieve是一种新的设备,旨在使用磁珠和体外电路选择性去除介质蛋白-6 (IL-6).

研究的目的:

评估IL-6-Sieve装置的安全性和可行性.
在动物模型和人类中评估磁性Anti-IL-6珠和体外电路组件的安全性.

主要方法:

用绵羊和小鼠进行的动物研究评估了设备组件和珠子生物分布的安全性.
首次对人进行的研究评估了健康志愿者体外电路的安全性.
安全性评估包括生命体征,常规实验室参数和不良事件监测.

主要成果:

在绵羊或人类参与者中没有观察到严重的不良事件.
静脉注射Anti-IL-6 Beads,无论是作为滥用场景还是按预期,都没有显示出对绵羊的重大安全问题.
在小鼠中的生物分布研究表明,没有意外的珠子积累.

结论:

最初的评估表明IL-6-Sieve是一种安全的血液净化方式.
需要进一步的研究来证实IL-6-Sieve在炎症疾病中的临床应用中的安全性和有效性.

更多相关视频

Synthesis of Cationized Magnetoferritin for Ultra-fast Magnetization of Cells

Synthesis of Cationized Magnetoferritin for Ultra-fast Magnetization of Cells

Published on: December 13, 2016

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Published on: September 18, 2015

相关概念视频

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

Imaging Studies I: CT and MRI

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...