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Updated: Jun 23, 2025

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对MDM2和TP53基因在犬类脂肪肉瘤中的分析

Luisa Vera Muscatello1, Dario de Biase2,3, Thais Maloberti4,3

  • 1Department of Veterinary Medical Sciences (DIMEVET), University di Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia, BO, Italy.

Scientific reports
|June 18, 2024
PubMed
概括

研究了犬类脂肪瘤的遗传特征,揭示TP53突变与myxoid亚型有关,与人类脂肪瘤不同. 狗脂肉瘤可能是一个独特的疾病.

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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