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Updated: May 15, 2026

Determination of Chemical Inhibitor Efficiency against Intracellular Toxoplasma Gondii Growth Using a Luciferase-Based Growth Assay
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从性淋巴瘤激酶抑制剂的结构导向转化为Plasmodium lysyl-tRNA合成酶选择性抑制剂

Jintong Zhou1,2, Mingyu Xia2, Zhenghui Huang3

  • 1School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sub-lane Xiangshan, Hangzhou, 310024, China.

Communications biology
|June 18, 2024
PubMed
概括

研究人员重新使用了一种形淋巴瘤激酶 (ALK) 抑制剂,以向疟疾寄生虫中的lysyl-tRNA合成酶 (LysRS). 类似的开发改善了对Plasmodium falciparum LysRS的功效,提供了新的抗疟疾药物策略.

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Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
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