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用VDTPACE或mCBAD进行密集的救援化疗,随后为耐火性/复发性多发性髓瘤提供血造干细胞支持

Carolina Perrone Marques¹, Danielle Ovigli¹, Mariana Nassif Kerbauy¹

¹Bone Marrow Transplant Department, Hospital Israelita Albert Einstein, São Paulo, Brazil.

European journal of haematology

|June 19, 2024

概括

在干细胞移植的支持下,像VDTPACE或mCBAD这样的强化化疗方案有效地减少了耐火性多发性髓瘤患者的疾病负担. 这种方法提供了一个可行的桥梁选项,具有可管理的毒性.

科学领域:

血液学血液学血液学
在瘤学瘤学.
干细胞移植干细胞移植

背景情况:

三重和四重耐火性多发性骨髓瘤呈现出具有侵略性的临床过程,治疗选择有限.
患有复发性或耐火性多发性骨髓瘤的患者通常面临着不良的预后.

研究的目的:

为了评估VDTPACE或mCBAD化疗方案的疗效和安全性,使用血造干细胞支持.
评估这些密集治疗方案的潜力,作为一座桥梁,以进一步治疗耐火性/复发性多发性骨髓瘤.

主要方法:

一项涉及13名耐火性/复发性多发性骨髓瘤患者的研究.
给予VDTPACE或mCBAD化疗,然后进行自身造血干细胞输液.
监测治疗反应,毒性和生存结果.

主要成果:

观察到高响应率,其中46%达到部分响应 (PR),46%达到非常好的部分响应 (VGPR),8%达到完全响应 (CR).
平均总生存时间为17个月,平均无进展生存时间为9个月.
感染性并发症是主要的毒性;没有报告的非复发性死亡率.

结论:

强化化疗方案可以显著降低复发性/耐药性多发性骨髓瘤的疾病负担.
造血干细胞支持减轻了毒性和与治疗相关的死亡率,将这些疗法定位为一种有价值的桥梁策略.

关键词:

弥合化疗的桥梁治疗.造血干细胞支造血干细胞支强化化学疗法强化化疗法.复发性/耐药性多发性骨髓瘤

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