相关实验视频
Updated: Jun 23, 2025

Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
在149匹具有与炎症性肠病相容的组织学变化的马匹中发现和预后
Lieuwke Cecilia Kranenburg1, Bo F Bouwmeester1, Robin van den Boom1
1Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, 3584 CM Utrecht, The Netherlands.
马的炎症性肠病 (IBD) 通常会导致体重减轻和表现不佳. 皮质类固醇治疗改善了大多数马的临床症状,提高了它们的一年生存率.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 胃肠病学 胃肠病学
- 马的健康 马的健康
背景情况:
- 炎症性肠病 (IBD) 是马的慢性肠道疾病.
- IBD的特点是肠道内炎症细胞透,导致各种临床症状.
研究的目的:
- 在被诊断患有十二指肠道IBD的马中记录临床和临床病理学发现.
- 评估IBD马的临床进展和生存率.
主要方法:
- 从内镜活检中对149匹具有十二指肠道IBD组织学证据的马进行了回顾性审查.
- 组织学变化被分级 (轻度,中度,严重),并确定了主要的细胞类型.
- 通过所有者问卷和医疗记录来评估临床改善和一年生存率.
主要成果:
- 常见的症状包括体重减轻,表现下降和腹痛.
- 大多数马的部分吸收不良;严重的IBD与较低的血清蛋白质相关.
- 淋巴细胞性肠炎是最常见的诊断 (78.5%),其次是中性友的透.
- 71%的马在六周内临床改善,主要是用皮质类固醇治疗.
结论:
- 皮质类固醇可以有效地控制马类IBD的临床症状.
- 六周内临床改善是对一年生存的积极预后指标.
- 十二指管活检结果本身并不是治疗结果的强有力的预测指标.
更多相关视频
08:07Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery
Published on: October 4, 2024
15:49Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Histology of the Small Intestine
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD: