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禁食诱导的影响肠道健康,因为它改变了肠道微生物群

Hao Zhang^1,2, Yihui Zhang^1,2, Yujie Gong^1,2

¹College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China.

Animals : an open access journal from MDPI

|June 19, 2024

概括

禁食诱导的在中会破坏肠道细菌,增加炎症. 特定的益生菌,如Ruminococcaceae UCG-013和Lactobacillus可以减轻这些对肠道健康的负面影响.

科学领域:

动物科学动物科学
微生物学微生物学
胃肠病学胃肠病学

背景情况:

禁食诱导的化 (FIM) 改善了老母的产卵性能,但可能导致肠道压力.
肠道菌群失衡和炎症是已知的FIM的后果.
在FIM期间肠道菌群变化的对肠道健康的具体影响需要阐明.

研究的目的:

调查FIM对产母肠损伤,微生物和代谢的影响.
了解FIM期间肠道微生物群变化与肠道健康之间的关系.
确定潜在的益生菌干预措施,以减轻FIM诱导的肠道炎症.

主要方法:

对肠道形态的分析,包括小的高度和小/密室比率.
微生物组分析,以评估禁食期间细菌组成的变化.
代谢分析以确定与肠道炎症相关的关键代谢物.
整合多omics数据以将微生物转移与生理变化相关联.

主要成果:

禁食显著降低了小的高度和小/密室比率,表明肠道受伤.
在禁食期间,肠道炎症和透性升高.
FIM改变了微生物群的组成,增加了Escherichia_Shigella,减少了Ruminococcaceae_UCG-013和乳杆菌.
Escherichia_Shigella与促炎代谢物 (Citrinin,Sterobilin) 相相关,而Ruminococcaceae_UCG-013和Lactobacillus与抗炎代谢物 (Lanthionine,减少的Glutathione) 相相关.

结论:

FIM诱导肠道损伤和炎症,部分由肠道微生物群失调作用.
鲁米诺可可菌种UCG-013和乳酸菌显示出作为益生菌减少FIM相关的肠道炎症的潜力.
针对肠道微生物群提供了一种策略,可以在母的FIM期间改善肠道健康.

关键词:

禁食诱导的变是因为禁食.肠道健康肠道健康代谢组代谢组的代谢我们的微生物群.

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