植物疗法用于治疗与代谢功能障碍相关的脂肪性肝病
Livhuwani P Nendouvhada1,2, Nicole R S Sibuyi1,3, Adewale O Fadaka1
1Department of Science and Innovation/Mintek Nanotechnology Innovation Centre, Biolabels Research Node, Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.
International journal of molecular sciences
|June 19, 2024
概括
植物合成的金属纳米粒子 (MNP) 显示出治疗代谢功能障碍相关的脂肪性肝病 (MASLD) 和相关疾病的前景. 需要进一步的研究来确认其临床使用的有效性和安全性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 纳米医学是一种纳米医学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,影响全球数百万人,并可能发展为严重的肝病,如肝硬化.
- 目前针对MASLD的治疗方法缺乏针对肝脏组织学的特定疗效,尽管它解决了相关代谢综合征 (MetS) 组件.
- 仍然不完全理解MASLD进展的潜在机制,突显出需要新的治疗策略.
研究的目的:
- 探索植物合成的金属基纳米颗粒 (MNP) 作为MASLD和代谢功能障碍相关的脂肪肝炎 (MASH) 的新治疗方法的潜力.
- 审查报告的MNP的生物活性,如金纳米粒子 (AuNPs) 和银纳米粒子 (AgNPs),以改善与MASLD相关的代谢参数.
主要方法:
- 关于MASLD,MASH,代谢综合征以及金属基纳米颗粒在代谢和肝脏疾病中的应用现有研究的文献综述.
- 分析了MNP对主要代谢指标的影响,包括血糖,身体脂肪和炎症.
主要成果:
- 植物合成的MNP具有独特的生物活性和减少旁观者影响,使它们成为治疗干预的有吸引力的候选人.
- 像AuNP和AgNP这样的特定MNP已经证明了改善代谢过程的潜力,包括降低血糖和炎症.
- 虽然植物疗法尚未为MASLD/MASH建立,但MNP的代谢益处表明在管理这些肝脏疾病方面可能发挥作用.
结论:
- 基于金属的纳米粒子 (MNPs) 是未来治疗MASLD/MASH和相关代谢障碍的有希望的途径.
- 进一步的临床前和临床研究至关重要,以验证植物农药对MASLD/MASH的治疗疗效和安全性.
- 通过针对MASLD中的肝脏病理和潜在的代谢障碍,MNP可以提供一种新的治疗策略.
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