解开口腔白血病中的氨酸表达:一个范围审查
Guru Murthy O1, Jeremy Lau1, Ramesh Balasubramaniam1
1UWA Dental School, The University of Western Australia, Nedlands, WA 6009, Australia.
International journal of molecular sciences
|June 19, 2024
概括
在口腔白血症中,氨酸表达的变化,特别是氨酸17的增加和氨酸13的损失,与发育不良有关. 需要进一步的研究来澄清质素.
科学领域:
- 细胞生物学 细胞生物学
- 生物化学 生物化学
- 在瘤学瘤学.
背景情况:
- 中间纤维由上皮细胞中的质蛋白组成,对细胞结构和功能至关重要.
- 氨酸功能与癌症的发展有关,而高氨酸化在口腔白血病中很常见.
- 质素作为口腔白血病的生物标志物的作用仍未得到充分研究.
研究的目的:
- 对人类口腔白血病组织中角质素表达的当前知识进行审查.
- 评估质素作为诊断,预后和预测生物标志物的有用性.
- 概述口腔白血病和发育不良症中1-20基拉丁的表达模式.
主要方法:
- 进行了对科学数据库 (PubMed,Scopus,Web of Science,OVID) 的范围审查.
- 1989年至2024年间发表的43项研究符合纳入标准.
- 分析了口腔白血病和宫发育不良病例中的氨酸表达.
主要成果:
- 发育不良症破坏了初级质素的终端分化途径.
- 增加了质素17和减少了质素13的表达被观察到在发育不良.
- 质蛋白1/质蛋白10的损失与高度发育不良相关;质蛋白19的延伸与发育不良相关.
- 只有五项研究探讨了质素的预后作用;没有一个评估了诊断或预测效用.
结论:
- 氨酸表达模式,包括K17增加,K13损失和K1/K10损失,与口腔上皮质发育不良有关.
- 关于细胞激素的预后价值存在相互矛盾的结果.
- 进一步的研究是必不可少的,以确定质蛋白作为可靠的生物标志物,用于预测口腔白血病的恶性转变.
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