代谢功能障碍相关的稳态性肝病:从发病到当前的治疗选择
Piero Portincasa1, Mohamad Khalil1, Laura Mahdi1
1Clinica Medica "A. Murri", Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari "Aldo Moro", 70124 Bari, Italy.
International journal of molecular sciences
|June 19, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题. 研究正在取得进展,寻找超越生活方式变化的个性化疗法,解决其复杂性质和高医疗负担.
科学领域:
- 肝病学和代谢疾病
- 药理学和治疗学 药理学和治疗学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 构成了全球显著且日益增加的健康负担.
- MASLD与严重的肝损伤有关,包括纤维化和癌症,并且独立地增加心脏代谢疾病和癌症的风险.
- 最近的术语转变 (NAFLD到MAFLD到MASLD) 反映了对其复杂病原性途径的日益增长的知识.
研究的目的:
- 审查目前对MASLD机制和治疗策略的理解.
- 突出了对MASLD表型的精确分类和创新治疗的需要.
- 强调多方利益相关者合作在管理MASLD及其预防方面的重要性.
主要方法:
- 审查有关MASLD病理生理学和治疗方法的当前文献.
- 分析不断发展的分类系统及其对治疗研究的影响.
- 药理学目标的探索,包括抗糖尿病药物,肠肝轴调节剂和全身性药物.
主要成果:
- 马斯尔德的复杂性质给单剂治疗的疗效带来了挑战.
- 目前正在研究各种药理学药物,包括FXR激活剂,PPAR激活剂和抗纤维素药物.
- 患者,医疗保健专业人员和行业之间的合作对于改善管理和预防至关重要.
结论:
- MASLD 管理需要采用多方面的方法,将生活方式的改变与新兴的药理疗法相结合.
- 准确的表型化对于开发针对MASLD/MASH的个性化和精确的治疗策略至关重要.
- 进展表明,MASLD的个性化医学的未来时代,解决其重大的健康和经济影响.
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