在接受全身治疗并接受基于乳清蛋白的营养支持的瘤患者的系统性炎症.
Aura D Herrera-Martínez1,2, Ana Navas Romo1,3, Soraya León-Idougourram1,2
1Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain.
乳清蛋白补充剂在接受治疗的癌症患者中没有改变循环中的细胞因子. 然而,手术和组合治疗降低了细胞因子水平,基线MCP-1独立预测死亡率.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 炎症在肉症和癌症进展中起着关键作用.
- 调节炎症是一种改善癌症患者治疗结果的潜在策略.
- 乳清蛋白具有抗炎和抗氧化特性.
研究的目的:
- 评估基于乳清蛋白的口服营养支持对癌症患者循环细胞因子的影响.
- 评估这些患者的营养状况,炎症和死亡率之间的关系.
主要方法:
- 46名正在接受全身治疗的固体瘤患者每天接受两次乳清蛋白补充剂.
- 对IL-6,IL-8,IL-10,MCP-1和IP-10的循环水平进行测量.
- 营养状况使用人体测量,仪器和生化参数进行评估.
主要成果:
- 在三个月的乳清蛋白补充后,没有观察到循环细胞因子水平的显著变化.
- 切除原发性瘤的患者表现出较低的IL-6和IP-10基线,并在补充后减少IL-8.
- 基线MCP-1被确定为死亡率的独立预测因子 (OR 1.03).
结论:
- 基于乳清蛋白的营养支持并没有改变癌症患者在三个月内循环中的细胞因子水平.
- 手术和联合治疗显著降低了循环中的细胞因子水平.
- 作为癌症患者的独立死亡因子,MCP-1需要进一步研究.
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