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吸烟对COPD患者临床和分子终点的影响
Patrizia Russo1,2, Francesca Milani1,2, Antonio De Iure1,3
1Department of Human Sciences and Promotion of the Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.
International journal of molecular sciences
|June 19, 2024
概括
在COPD患者中,吸烟显著增加了DNA损伤和炎症. 前吸烟者面临较低的生存率,这突显了吸烟对呼吸系统健康的长期影响.
科学领域:
- 肺病学和环境健康
- 分子生物学和毒理学
背景情况:
- 慢性阻塞性肺病 (COPD) 是全球主要的健康负担,与吸烟密切相关.
- 吸烟引起的氧化应激和炎症是导致COPD病原和进展的关键机制.
研究的目的:
- 研究吸烟史对临床参数,氧化应激标志物和老年COPD患者DNA损伤的影响.
- 评估COPD患者吸烟状态,炎症和生存率之间的关系.
主要方法:
- 对87名老年COPD患者的横截面研究分为现有,前任和从未吸烟者.
- 评估临床特征 (并发症,生存),炎症/氧化标志物 (例如,血小板/淋巴细胞比,MDA,8-Oxo-dG,IL6),以及DNA损伤 (彗星测定).
- 检测病毒感染,包括A型流感 (H1N1),JC型多瘤病毒 (JCPyV),BK型多瘤病毒 (BKPyV) 和Torquetenovirus (TTV).
主要成果:
- 当前吸烟者表现出更高的并发病率,血小板/淋巴细胞比率,全身炎症和DNA损伤.
- 与从未吸烟和目前吸烟者相比,前吸烟者显示氧化损伤标志物增加,并且5年生存概率明显降低.
- 在氧化途径事件和吸烟之间观察到显著的相互作用.
结论:
- 吸烟与COPD患者的DNA损伤,炎症和并发症的增加直接相关.
- 前吸烟者代表了一个脆弱的群体,生存率降低,可能是由于持续的健康问题.
- DNA损伤,炎症参数和病毒感染是监测COPD患者进行肺部康复的重要标志物.
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