实验性自身免疫脑炎影响雌性大鼠GH轴
Anica Zivkovic1, Svetlana Trifunovic2, Danijela Savic1
1Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic"-National Institute of Republic of Serbia, University of Belgrade, 11108 Belgrade, Serbia.
International journal of molecular sciences
|June 19, 2024
概括
这项研究揭示了增长激素 (GH) 和类似胰岛素的增长因子-1 (IGF-1) 轴活性在实验性自身免疫脑膜炎 (EAE) 期间发生的变化,这是多发性硬化症模型. 研究结果表明GH耐药性,可能会影响治疗策略.
科学领域:
- 神经免疫学 神经免疫学
- 内分泌学 在内分泌学.
- 自免疫性疾病 自免疫性疾病
背景情况:
- 多发性硬化症 (MS) 涉及中枢神经系统 (CNS) 炎症,脱髓化和轴突损伤.
- 增长激素 (GH) /胰岛素类增长因子-1 (IGF-1) 轴在免疫调节中发挥作用,但其与MS/EAE的联系尚不清楚.
研究的目的:
- 在急性实验性自身免疫脑膜炎 (EAE) 期间调查GH轴的变化.
- 探索GH/IGF-1轴变化与EAE疾病严重程度之间的关系.
主要方法:
- 在EAE期间对下丘脑和垂体腺体基因表达的分析.
- 对血清GH和IGF-1水平的测量.
- 对GH和IGF-1受体的肝脏基因表达的评估.
主要成果:
- 对Ghrh和Sst的下丘脑基因表达保持不变,而Npy和Agrp则发生变化.
- 下垂体Gh,Ghrhr和Ghr基因表达被上调;体质细胞体积没有变化.
- 血清GH的升高与低IGF-1和低调的肝脏GHR/Igf1r表达表明GH耐药性.
结论:
- 急性EAE的特征是GH耐药性的状态,可能与中枢神经系统炎症高峰期营养摄入量减少有关.
- GH/IGF-1轴在MS/EAE病变发生过程中具有重要作用,需要进一步研究治疗潜力.
关键词:
欧洲电子商务管理局 (EEAE)在IGF-1的基础上,IGF-1增长激素增长激素的使用方法pituitary pituitary pituitary pituitary pituitary pituitary pituitary pituitary pituitary pituitary pituitary 下垂体 下垂体 下垂体 下垂体 下垂体 下垂体 下垂体 下垂体更多相关视频
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