三阴性乳腺癌EVs调节正常上皮肺细胞的生长和迁移
Ilaria Leone1, Jessie Santoro1, Andrea Soricelli1
1IRCCS SYNLAB SDN, Via E. Gianturco, 80143 Naples, Italy.
International journal of molecular sciences
|June 19, 2024
概括
三阴性乳腺癌细胞释放细胞外囊泡 (EVs),促进肺上皮细胞的生长,迁移和侵入性. 这表明,EVs可能在癌症进展和早期检测中发挥作用.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 癌症转移研究 癌症转移研究
背景情况:
- 乳腺癌是全球女性的主要癌症,由于早期检测,其存活率增加.
- 肺转移是乳腺癌的常见并发症,通常在诊断后五年内发生.
- 细胞外囊泡 (EVs) 与细胞间通信和癌症进展有关.
研究的目的:
- 研究来自三阴性乳腺癌 (TNBC) 的EVs对正常肺上皮细胞的影响.
- 分析TNBC衍生的EV如何影响肺细胞的生物行为.
主要方法:
- 使用差异超离心法将EV从TNBC细胞系 (MDA-MB-231,HS578T) 中分离出来.
- 人类肺上皮细胞系 (BEAS-2B) 的治疗与孤立的TNBC EVs.
- 评估随着时间的推移,肺细胞生长,迁移和侵入性的变化.
主要成果:
- 来自TNBC的EV显著增加了正常肺上皮细胞的生长.
- 暴露于TNBC EVs增强了肺上皮细胞的迁移和侵入性.
- 与没有EV治疗的对照组相比,观察到这些效应.
结论:
- 由TNBC细胞释放的EV含有促进正常肺细胞中前瘤活性的因素.
- 这些发现强调了EVs在调解乳腺癌肺转移中的潜在作用.
- 电动汽车及其货物为癌症早期检测和诊断中的新生物标志物提供了有希望的途径.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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