基于氏丁硫酸盐的纳米囊作为药物和营养补充剂的纳米载体
Magdalena Górniewicz1,2, Dawid Wnuk3, Aleksander Foryś4
1Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.
International journal of molecular sciences
|June 19, 2024
概括
开发了新的基于氏丁硫酸盐 (CS) 的纳米囊 (NC) 与油芯. 这些生物相容的NC有望在局部输送脂友化合物方面发挥作用.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物相容性材料 生物相容性材料
背景情况:
- 油芯纳米囊 (NCs) 是有价值的 lipophilic 生物活性物质的载体.
- 氏丁硫酸盐 (CS) 是一种生物相容的多糖,具有NC配方的潜力.
研究的目的:
- 为了合成和表征新的基于CS的纳米囊 (NCs) 与液态油芯.
- 评估这些NC的生物相容性和其在局部输送脂性化合物的潜力.
主要方法:
- 两性CS衍生物 (AmCSs) 通过与八甲基或基接种的合成.
- 超声波辅助乳化,用于制备基于AMCS的NC,使用甘油三和维生素E.
- 使用动态光散射和冷传输电子显微镜进行表征.
- 在体外细胞毒性和细胞增殖测定中,使用人类角质细胞 (HaCaTs) 和皮肤纤维细胞 (HSF).
主要成果:
- 成功准备了直径为30-250nm的球形基于CS的NC.
- AmCS和它们的NC表现出不同的细胞毒性;NC,特别是那些含有维生素E的,与皮肤细胞具有很高的生物相容性.
- NCs在生理条件下表现出稳定性和对疏水化合物的高封装效率.
结论:
- 两性CS衍生物可以形成稳定,生物相容的油芯纳米囊.
- 基于CS的NC是有前途的载体,可用于局部输送脂友生物活性物质,包括维生素E.
- 该研究强调了基于CS的纳米载体在皮肤和化品应用中的潜力.
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