循环中的三甲基胺-N-氧化物在肝移植接受者中升高
Maria Camila Trillos-Almanza1, Mateo Chvatal-Medina1, Margery A Connelly2
1Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
International journal of molecular sciences
|June 19, 2024
概括
甲基胺-N-氧化物 (TMAO) 在肝移植接受者 (LTRs) 中升高,可能与功能受损和铁使用有关. 在LTR中较高的TMAO水平可能表明死亡风险增加.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肝病学 肝病学是一种肝病学.
- 生物标志物发现发现
背景情况:
- 与普通人群相比,肝移植接受者 (LTR) 的长期存活率较低.
- 确定移植后死亡风险的生物标志物对于改善患者的治疗结果至关重要.
研究的目的:
- 为了比较稳定的LTR与普通人群中的血三甲基胺-N-氧化物 (TMAO) 水平.
- 调查影响LTRs中TMAO水平的因素.
- 评估血TMAO与LTRs所有原因死亡率之间的关联.
主要方法:
- 血TMAO水平测量了367名稳定的LTR (移植线队列) 和4837名普通人口参与者 (PREVEND队列).
- 使用统计分析,包括多变量回归和生存分析,以确定TMAO水平,决定因素和死亡率相关性.
主要成果:
- 与一般人群 (3.2μmol/L) 相比,LTRs (4.3μmol/L) 的TMAO水平显著更高 (35%).
- 在具有特定肝病病因的LTR中观察到TMAO升高,包括与代谢功能障碍相关的脂肪性肝病和与酒精相关的肝病.
- 血TMAO与估计的膜过率 (eGFR) 和铁补充剂在LTRs中独立相关.
- 较高的TMAO水平与LTRs所有原因死亡风险的增加有关 (HR 4.14).
结论:
- 血TMAO在稳定的LTR中升高,EGFR受损和铁补充作为潜在的促成因素.
- 初步发现表明,血TMAO可能是增加LTRs死亡风险的潜在生物标志物.
- 需要进一步的严格研究来验证这些发现,并确认TMAO在LTR死亡率中的作用.
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