海产素及其半合成衍生物降低IL6水平,改善人类肝细胞癌细胞中的胰岛素信号传递
Ayewa L Agognon1, Marcello Casertano2, Alessio Vito2
1Department of Translational Medicine, Federico II University of Naples and URT "Genomic of Diabetes" of Institute of Experimental Endocrinology and Oncology, National Council of Research (CNR), Via Pansini 5, 80131 Naples, Italy.
International journal of molecular sciences
|June 19, 2024
概括
海洋化合物烯 (PE) 和其衍生品PE/2通过改善肝脏胰岛素信号传递和减少肝细胞中的插白素-6 (IL6) 来增强胰岛素敏感性.
科学领域:
- 海洋天然产品 海洋天然产品
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 海洋天然产品是新型抗糖尿病药物发现的有希望的来源.
- 肝脏对胰岛素的抵抗是2型糖尿病的关键因素.
- 介质素-6 (IL6) 涉及损害胰岛素的作用.
研究的目的:
- 为了研究脂素 (PE) 和其衍生物 (PE/2,PE/3) 对 HepG2 细胞胰岛素敏感性的影响.
- 评估PE及其衍生物对胰岛素受体 (INSR) 和AKT酸化的影响.
- 评估PE及其衍生物对IL6分泌和表达的影响.
主要方法:
- 使用了人类肝细胞癌 (HepG2) 细胞.
- 测量了INSR和AKT的胰岛素诱导酸化.
- 评估了IL6和PEPCK的表达和分泌.
主要成果:
- PE,PE/2和PE/3显著增强了胰岛素诱导的INSR和AKT酸化.
- PE和PE/2对降低PEPCK表达具有添加效应.
- 在基底和棕酸条件下,PE和PE/2降低了IL6的分泌和表达;在高葡萄糖条件下,PE也降低了IL6.
结论:
- 烯 (PE) 和其衍生品PE/2可以改善肝脏胰岛素信号传递.
- PE和PE/2可以降低IL6,它是胰岛素抵抗的关键媒介.
- 这些海洋化合物有可能为糖尿病开发新的治疗策略.
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