NOS2和COX-2的共同表达促进癌症的进展:一种潜在的目标,用于开发预防或治疗高度侵袭性乳腺癌的药物

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Leandro L Coutinho^1,2, Elise L Femino¹, Ana L Gonzalez¹

¹Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

International journal of molecular sciences

|June 19, 2024

概括

氧化 (NO) 和反应性物种 (RNS) 是癌症的关键. 了解它们在瘤微环境 (TME) 中的化学生物学和空间分布对于开发向疗法至关重要.

科学领域:

化学生物学是化学生物学.
癌症研究癌症研究
分子生物学分子生物学

背景情况:

氧化 (NO) 和活性物种 (RNS) 具有由其化学性质决定的关键生物功能.
它们的空间分布对于理解它们在生物过程中的作用至关重要,特别是在癌症中.

研究的目的:

为癌症中NO和RNS的化学生物学建立框架.
探索NO的度依赖信号及其对致癌性质的影响.
研究NOS2和COX-2在癌症进展和瘤微环境 (TME) 中的相互作用.

主要方法:

关于癌症中NO和RNS化学和生物学现有文献的综述.
对NO在癌细胞信号传递中的度依赖作用的分析.
在TME中检查NOS2和COX-2的空间表达和共同表达模式.
讨论针对NO和RNS通路的治疗策略.

主要成果:

NO对癌细胞增殖,转移,化疗耐药性和免疫抑制有影响.
增加NOS2表达与生存率差相关,并且它可以与COX-2交叉交谈,以促进癌症的进展.
在ER阴性乳腺癌中,NOS2和COX-2的共同表达产生了一个前循环,驱动免疫抑制和转移.
空间分析显示,NOS2和COX-2在不同的TME中的正交表达,需要IFN-γ和细胞因子释放细胞.

结论:

了解NO和RNS的化学生物学和空间分布对于癌症研究至关重要.
准NOS2和COX-2,可能与来自十字植物蔬菜的化合物,提供了治疗途径.
这些见解对于开发向治疗和预防癌症的预防策略非常有价值.

关键词:

生物化学生物化学乳腺癌乳腺癌乳腺癌氧化氧化的使用方法治疗疗法治疗疗法治疗疗法

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