目前的新针对性治疗策略在多发性骨髓瘤中
Cindy Hsin-Ti Lin1, Muhammad Junaid Tariq2, Fauzia Ullah3
1Department of Internal Medicine, Case Western Reserve University, MetroHealth Campus, Cleveland, OH 44109, USA.
International journal of molecular sciences
|June 19, 2024
概括
针对特定分子的新型治疗方法为多发性骨髓瘤 (MM),一种血液癌症提供了新的希望. 对这些新兴疗法的研究对于克服耐药性和改善患者对这种无法治愈的疾病的治疗结果至关重要.
科学领域:
- 血质性恶性病变 血质性恶性病变
- 癌症生物学 癌症生物学
- 药物发现 药物发现 药物发现
背景情况:
- 多发性骨髓瘤 (MM) 是一种血细胞恶性瘤,具有常见的衰弱症状.
- 目前的MM治疗面临的挑战是长期有效性有限,复发频繁.
- 耐药性和途径改变需要探索新的治疗点.
研究的目的:
- 提供针对多发性骨髓瘤的新型治疗方法的全面概述.
- 根据它们的分子标对新兴疗法进行分类.
- 突出MM疗法持续研究的重要性.
主要方法:
- 关于多发性骨髓瘤治疗的最新进展的文献综述.
- 根据分子标对新疗法的分类.
- 免疫调节药物,NK细胞疗法和向蛋白质分解的仿真体的描述.
主要成果:
- 确定了包括BCMA,GPRC5D,FcRH5,CD38,SLAMF7,BCL-2等在内的关键分子标.
- 讨论了新兴的治疗策略,如免疫调节药物和NK细胞疗法.
- 突出了向蛋白质分解的嵌合体作为一个有前途的治疗方法.
结论:
- 针对特定分子通路的新型疗法显示出克服MM药物耐药性的前景.
- 对这些新兴治疗方法的持续研究对于改善多发性骨髓瘤的结果至关重要.
- 解决治疗限制性毒性和疾病复发仍然是MM治疗的关键目标.
更多相关视频
05:32Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
Published on: January 7, 2019
6.8K
10:04Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
13.1K
相关概念视频
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:27Tumor Immunotherapy
511
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
511
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
02:56Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K