儿童潜在的腹腔疾病:长期含质饮食的健康状况
Roberta Mandile1,2, Federica Lerro1, Martina Carpinelli1,2
1Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Nutrients
|June 19, 2024
概括
在含饮食 (GCD) 上,可能患有乳病 (PCD) 的无症状儿童没有长期的营养或自身免疫并发症. 他们的抗体水平下降,健康标志物在3年随访期间改善或保持稳定.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 潜在的乳性疾病 (PCD) 是通过阳性乳性疾病 (CD) 特定的血清学和正常的肠道组织学来定义的.
- 目前的指导方针经常建议无症状PCD患者食用含质饮食 (GCD),但长期风险尚不清楚.
研究的目的:
- 调查长期潜在的营养和自身免疫并发症在无症状的儿童PCD维持在GCD.
- 评估这个群体随着时间的推移增长,营养状况和自身免疫的变化.
主要方法:
- 在GCD上对171名无症状的PCD儿童进行了随访,平均为3年.
- 包括生长,营养状况 (例如血红蛋白,维生素D) 和自身免疫 (抗组织转质胺酶抗体) 在诊断和随访期间的参数进行了比较.
主要成果:
- 尽管继续摄入谷蛋白,但抗组织转谷氨酶 (anti-TG2) 抗体自发显著下降.
- 大多数营养和生长参数保持稳定或显著改善 (例如体重,BMI,血红蛋白),均处于正常范围内.
- 其他自身免疫性疾病的自身抗体没有增加,当排除特定亚组时,结果是一致的.
结论:
- 在可能患有乳症的无症状儿童中维持含的饮食似乎在长期内是安全的.
- 这项试点研究表明,即使随着长期的随访,在这个人群中,与GCD相关的营养或自身免疫风险并不显著.
相关概念视频
Overview of Protein Metabolism
1.0K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.0K
Other Disorders of Digestive System
778
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
778
Inborn Errors of Metabolism
155
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
155
Cystic Fibrosis: Pathogenesis
208
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
208
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Diabetes: Symptoms, Diagnosis, and Complications
522
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
522


