在IBS患者便短链脂肪酸的变化和不同干预措施的影响:系统性审查和元分析
Xuan Ju1, Zhenliang Jiang1, Jiayin Ma1
1Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, China.
便 propionate 在刺激性肠综合征 (IBS) 患者中较高,酸盐较低. 低FODMAP饮食可以治疗IBS,但便微生物群移植和益生菌需要进一步研究.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 代谢学 代谢学 代谢学
背景情况:
- 关于短链脂肪酸 (SCFA) 与刺激性肠综合征 (IBS) 病因之间的关联,存在相互矛盾的报道.
- SCFA 在肠道健康和功能中起着至关重要的作用.
- 了解IBS中的SCFA变化对于诊断和治疗至关重要.
研究的目的:
- 系统地审查IBS患者便SCFAs的病例控制研究和RCT.
- 为了确定潜在的SCFA生物标志物用于IBS诊断.
- 评估干预措施的有效性,如低FODMAP饮食,便微生物群移植 (FMT) 和益生菌在IBS中的SCFA水平.
主要方法:
- 在PubMed,Web of Science和Embase数据库中的系统文献搜索.
- 包括2023年2月24日之前发表的21项研究.
- 数据由三个独立审查员提取.
主要成果:
- 与健康对照组相比,IBS患者表现出明显更高的便 propionate 和较低的酸盐比例.
- 在IBS患者中,低FODMAP饮食显著降低了便 propionate.
- FMT和益生菌的使用并没有显著改变便 propionate或酸盐水平.
结论:
- 便 propionate 和酸盐度显示出作为IBS诊断生物标志物的潜力.
- 低FODMAP饮食干预可能是IBS的可行的治疗策略.
- 需要进一步严格的试验来确认FMT和益生菌在IBS治疗中的有效性.
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